Curare

$813,00

Human weight: no more than 140 kg
Form: liquid
Composition: curare
Country of origin: India
Active ingredient: curare
Concentration: 97%
Weight: 20 ml

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Description

Curare is the general name for a group of plant poisons containing alkaloids (primarily tubocurarine, C37H41N2O6⁺), obtained from the bark and vines of South American plants of the genera Chondrodendron and Strychnos.
It was used by Amazonian Indians to lubricate arrows and darts.
In medicine, tubocurarine was previously used as a muscle relaxant during surgery and artificial ventilation (in minimal doses).

Curare is a neurotoxin that blocks nerve impulse transmission to skeletal muscles.

It acts as a competitive antagonist of acetylcholine at neuromuscular synapses.

It causes paralysis of the respiratory muscles while maintaining consciousness.

It does not affect sensation or consciousness—the person dies fully conscious.

Lethal dose:
For an adult, approximately 5-10 mg of pure alkaloid.

Toxicity decreases sharply with skin absorption.

Time to death:
After intramuscular or intravenous administration, death occurs within 5-15 minutes due to respiratory arrest.

With small doses, death is possible within 30-60 minutes due to asphyxia without cardiac damage.

Consciousness is maintained until the very end.

Signs of poisoning:
• General weakness, loss of mobility
• Difficulty breathing, feeling of suffocation
• Inability to speak or move limbs
• Drop in blood pressure, bluish skin
• Complete paralysis while remaining conscious
• Death from asphyxia and cerebral hypoxia

Difficult to detect due to rapid breakdown in the body.
Detected using HPLC, IR spectroscopy, and enzyme-linked immunosorbent assays in blood, urine, and muscle.
Remains in tissues for up to 24 hours after death; traces of metabolites persist for up to 3 days.

A characteristic morphological sign is death from paralysis of the respiratory muscles with a preserved pulse and normal cardiac morphology.

Store in sealed glass bottles, protected from light, away from acids and alkalis.
Avoid contact with skin and mucous membranes.
Shelf life: no more than 12 months.